                         SEQUENCE LISTING

<110>  NAICONS S.c.a.r.l.
       Istituto Italiano di Tecnologia (IIT).
 
<120>  Novel lantipeptide

<130>  10465M35

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  132
<212>  DNA
<213>  Actinoplanes sp. DSM 24059


<220>
<221>  misc_feature
<222>  (1)..(132)
<223>  gene 112-labA  as isolated from Actinoplanes sp. DSM 24059

<400>  1
gtgcaggaga tcctggagct gcaggagctg ccgtcggcct cggccacgga ggacatgccg       60

ctggtcagca cgctcagcgt cagctcgccg tgccccggct ggccgagctc cttcacctgg      120

tcgaactgct ga                                                          132


<210>  2
<211>  43
<212>  PRT
<213>  Actinoplanes sp. DSM 24059

<400>  2

Val Gln Glu Ile Leu Glu Leu Gln Glu Leu Pro Ser Ala Ser Ala Thr 
1               5                   10                  15      


Glu Asp Met Pro Leu Val Ser Thr Leu Ser Val Ser Ser Pro Cys Pro 
            20                  25                  30          


Gly Trp Pro Ser Ser Phe Thr Trp Ser Asn Cys 
        35                  40              


<210>  3
<211>  22
<212>  PRT
<213>  Actinoplanes sp. DSM 24059


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-terminal residue belonging to the carbacyclic post 
       translationally modified amino acid labionin (Lab)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Amino acid in position 3 is Dehydrobutyrine (Dhb) an unusual 
       Amino Acid. Synthetase enzymes catalyze the dehydration of Thr 
       residue in its peptide substrate to Dhb.

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  central residue belonging to the carbacyclic post translationally
       modified amino acid labionin (Lab)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  C-terminal residue belonging to the carbacyclic post 
       translationally modified amino acid labionin (Lab)

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  N-terminal residue belonging to the carbacyclic post 
       translationally modified amino acid  methyl-labionin (Me-Lab)

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Amino acid in position 16 is dehydroalanine  (Dha), an unusual 
       amino acid. Synthetase enzymes catalyze the dehydration of Ser 
       residue in its peptide substrate to Dha.

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  central residue belonging to thecarbacyclic post translationally 
       modified amino acid methyl-labionin (Me-Lab)

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  C-terminal residue belonging to thecarbacyclic post 
       translationally modified amino acid  methyl-labionin (Me-Lab)

<400>  3

Val Xaa Xaa Leu Xaa Val Ser Ser Pro Xaa Pro Gly Trp Pro Xaa Xaa 
1               5                   10                  15      


Phe Xaa Trp Ser Asn Xaa 
            20          


<210>  4
<211>  22
<212>  PRT
<213>  Actinoplanes sp. DSM24059


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-terminal residue belonging to the carbacyclic post 
       translationally modified amino acid labionin (Lab)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Amino acid in position 3 is Dehydrobutyrine (Dhb) an unusual 
       Amino Acid. Synthetase enzymes catalyze the dehydration of Thr 
       residue in its peptide substrate to Dhb.

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  central residue belonging to thecarbacyclic post translationally 
       modified amino acid labionin (Lab)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  C-terminal residue belonging to the carbacyclic post 
       translationally modified amino acid labionin (Lab)

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  N-terminal residue belonging to the carbacyclic post 
       translationally modified amino acid methyl-labionin (Me-Lab)

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  central residue belonging to the carbacyclic post translationally
       modified amino acid methyl-labionin (Me-Lab)

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Amino acid in position 20 is dehydroalanine  (Dha), an unusual 
       amino acid. Synthetase enzymes catalyze the dehydration of Ser 
       residue in its peptide substrate to Dha.

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  C-terminal residue belonging to the carbacyclic post 
       translationally modified amino acid methyl-labionin (Me-Lab)

<400>  4

Val Xaa Xaa Leu Xaa Val Ser Ser Pro Xaa Pro Gly Trp Pro Xaa Ser 
1               5                   10                  15      


Phe Xaa Trp Xaa Asn Xaa 
            20          


<210>  5
<211>  1419
<212>  DNA
<213>  Actinoplanes sp. DSM24059


<220>
<221>  misc_feature
<222>  (252)..(252)
<223>  n is a, c, g, t or u

<400>  5
gcggcgtgct taacacatgc aagtcgagcg gaaaggccct tcggggtact cgagcggcka       60

acgggtgagt aacacgtgag aaacctgccc tggactttgg gataaccctc ggaaacgggg      120

gctaataccg aatacgactt accctcgcat gggggttggt ggaaagtttt tcggtctggg      180

atggtctcgc ggcctatcag cttgttggtg gggtaatggc ctaccaaggc gacgacgggt      240

agccggcctg anagggcgac cggccacact gggactgaga cacggcccag actcctacgg      300

gaggcagcag tggggaatat tgcacaatgg gcggaagcct gatgcagcga cgccgcgtga      360

gggatgacgg ccttcgggtt gtaaacctct ttcagcaggg acgaagcgca agtgacggta      420

cctgcagaag aagcgccggc caactacgtg ccagcagccg cggtaagacg tagggcgcga      480

gcgttgtccg gatttattgg gcgtaaagag ctcgtaggcg gcttgtcgcg tcgactgtga      540

aaacccgcgg ctcaaccgcg ggcctgcagt cgatacgggc aggctagagt tcggtagggg      600

agactggaat tcctggtgta gcggtgaaat gcgcagatat caggaggaac accgatggcg      660

aaggcaggtc tctgggccga tactgacgct gaggagcgaa agcgtgggga gcgaacagga      720

ttagataccc tggtagtcca cgctgtaaac gttgggcgct aggtgtgggg gacctctccg      780

gttctctgtg ccgcagctaa cgcattaagc gccccgcctg gggagtacgg ccgcaaggct      840

aaaactcaaa ggaattgacg ggggcccgca caagcggcgg agcatgcgga ttaattcgat      900

gcaacgcgaa gaaccttacc tgggtttgac atcgccggaa aactcgcaga gatgcggggt      960

ccttcggggc cggtgacagg tggtgcatgg ctgtcgtcag ctcgtgtcgt gagatgttgg     1020

gttaagtccc gcaacgagcg caaccctcgt tcgatgttgc cagcgcgtta tggcggggac     1080

tcatcgaaga ctgccgggtc aactcggagg aaggtgggga tgacgtcaag tcatcatgcc     1140

ccttatgtcc agggcttcac gcatgctaca atggccggta caaagggctg cgataccgtg     1200

aggtggagcg aatcccaaaa agccggtctc agttcggatc ggggtctgca actcgacccc     1260

gtgaagtcgg agtcgctagt aatcgcagat cagcaacgct gcggtgaata cgttcccggg     1320

ccttgtacac accgcccgtc acgtcacgaa agtcggcaac acccgaagcc ggtggcctaa     1380

cccgtaaagg gagggagccg tcgaaggtgg ggctggcga                            1419


